The Hematological and Histopathological changes of Giardia duodenalis on the intestine in Diyala Government

Abstract

Giardia duodenalis is one of the most prevalent human intestine protozoan parasites in the world and infected a broad variety hosts of animals, The goal of the current study was to determine the hematological picture and histopathological changes of intestine in rabbits. 15 rabbits used in this study for 2 months divided into 3 groups: 1st group the control its normal feed and water without any treatment, 2nd group given one dose orally weekly of Giardia cyst for 2 months, 3rd group given two dose orally weekly of Giardia cyst for 2 months. The results of hematological analysis between control group and treated groups at one and two months revealed a statistically significant difference (P<0.05) decrease in the mean of the following RBC count, Hb, PCV, platelets and increase of WBC count, monocytes and lymphocytes, also the pathological changes were observed grossly and histopathological in intestine including hyperplasia in colonic glands and mucosa, increase no. of goblet cells and aggregation of parasites in mucosa.