Histopathological Effect of Pecan Oil (Carya illinoinensis) against Ibuprofen induced Kidney Injury in Local Male Rabbits

Abstract

Ibuprofen is considered one of the important medications used to relieve pain, as it belongs to non-steroidal anti-inflammatory drugs. In addition to being inexpensive, it is necessary to relieve many types of pain, especially after surgery. In current study, twenty local male rabbits, divided equally into four groups. The 1st group received normal saline orally, 2nd group received ibuprofen 20mg/kg orally, 3rd group received 40mg/kg orally and the 4th group received pecan oil extract orally, after 3 hours received ibuprofen syrup orally. The experimental study continues for 28 days. The results observed the control group which received normal saline not showed any abnormalities in structures of the kidney. The second group which received ibuprofen 20mg/kg orally for 28 days showed congestion of blood vessels, infiltration of inflammatory cells, dilated blood vessels and hydropic degeneration. The third group which received 40mg/kg orally for 28 days showed fatty changes and eosinophilic material. In addition to highly congestion of blood vessels, cloudy swelling, hemolysis of RBC and infiltration of inflammatory cells. The fourth group which pecan oil extract orally, after 3 hours received ibuprofen syrup orally for 28 days showed normal structures of rabbit kidneys. Current study exhibit agreement with other about adverse effect of ibuprofen by appeared histopathological lesion on the kidney and in same time reported the beneficial effect of pecan oil on the kidney structures.