Biochemical and histopathological effect of ketorolac on liver and kidney of local male rabbits

Abstract

Ketorolac is anti-inflammatory analgesic drug which have high activity to reduce pain, used in
rabbits, primary in ocular operation. In current study, the aim of it to obvious the biochemical
and histopathological effect caused by ketorolac on liver and kidney of the rabbits. Thirty local
male rabbits were used, the rabbits divided equally and randomly into three groups, first control
group, second group and third group ,each group consist of ten rabbits and the study continuous
for 14 days. The Biochemical result of this study revel normal value in first control group, the
second and third group showed significant increase in the liver enzyme, creatinine, bilirubin
and nitrogen urea. Histopathological changes showed normal histological structures of liver
and kidney in control group. Liver in second group showed cellular necrosis and hemorrhage
at 15 mg/kg of ketorolac, while injection of 30 mg/kg in third group, the liver showed complete
destruction of cell membrane. Kidney in second group showed hemorrhage at 15 mg/kg of
ketorolac while injection of 30 mg/kg of ketorolac in third group, the kidney showed glomerular
atrophy, bowman space dilation, collapsed tuft, degenerated tubules and cellular necrosis.